Formaldehyde, aspartame, and migraines: a possible connection.

Systemic contact dermatitis of the eyelids caused by formaldehyde derived from aspartame?

Formaldehyde derived from dietary aspartame binds to tissue components in vivo.

Adult male rats were given an oral dose of 10 mg/kg aspartame 14C-labelled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (>98% in plasma, >75% in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of 1-2% of total radioactivity administered per g o...

Formaldehyde Derived from Dietary Aspartame Binds to Tissue Components in Ku’0

Adult male rats were given an oral dose of 10 mgkg aspartame “C-1abelled in the methanol carbon. At timed intervals of up to 6 hours, the radioactivity in plasma and several organs was investigated. Most of the radioactivity found (>98 % in plasma, >75 % in liver) was bound to protein. Label present in liver, plasma and kidney was in the range of l-2 % of total radioactivity administered per g ...

Serum biochemical responses under oxidative stress of aspartame in wistar albino rats

Aspartame is widely consumed by humans who are diabetic and who are under weight loss regime. Aspartame (L-aspartyl-L-phenylalanine methyl ester) also known as NutraSweet, after oral administration to humans and experimental animals, aspartame is rapidly and completely metabolized to 50% phenylalanine, 40% aspartic acid and 10% methanol[1]. Methanol is being increasingly recognized as a substan...

Does aspartame cause methanol toxicity?

Sir,—Digestion of the sweetener aspartame yields aspartic acid and phenylalanine, plus methanol. has questioned aspartame's safety, alleging (1) that methanol is a "cumulative poison", (2) that a toxicity syndrome is producible "only in humans", (3) that "formaldehyde is a known carcinogen", (4) that ethanol protects against methanol in food sources, (5) that the. Environmental Protection Agenc...